Dr. Sweet is Director of the Clinical Neuroscience Laboratory (CNS-Lab). It is a neuroimaging data analysis and neuropsychological assessment laboratory affiliated with the Clinical Psychology and Brain and Behavioral Science Programs in the Department of Psychology and the interdisciplinary Neuroscience Program at UGA. The CNS-Lab integrates multimodal neuroimaging and neuropsychological assessments with other clinical research methodology to examine brain-behavior relationships. The CNS-Lab specializes in experimental design, and data acquisition, analyses, and interpretation for clinical and non-clinical studies that employ functional magnetic resonance imaging (fMRI), perfusion MRI (arterial spin labeling techniques), and structural morphometry (e.g., volumetrics, cortical thickness, lesion quantification). The CNS-Lab is responsible for data analyses and consultation for several local and multi-site clinical research studies.
Ph.D., Rosalind Franklin University of Medicine and Science
I examine brain-behavior relationships in clinical populations using cognitive and affective neuroscience techniques, particularly multimodal neuroimaging and neuropsychological assessments. My FMRI work includes paradigm development with a focus on clinically relevant constructs (e.g., objective assessments of subjective states, prediction of treatment outcome). Recent studies include the use of functional neuroimaging markers to predict smoking cessation outcome; functional, structural and prefusion MRI correlates of cognitive function in cardiovascular disease; the effects of early life stress on adult cognitive function; cue reactivity in obesity and nicotine dependence; and working memory and information processing speed in subcortical disease processes.
Sweet, LH, MacKillop, J, Amlung, M (in press). Functional Neuroimaging in Addictions Research. In J Mackillop and H de Wit (Editors). The Wiley-Blackwell Handbook of Addiction Psychopharmacology. Wiley-Blackwell, New York.
Sweet, LH, Hassenstab, J, McCaffery, JM, Haley, AP, Bond, D, Raynor, HA, Del Parigi, A, Cohen, R, Wing, RR (2012). Brain response to food stimulation in obese, normal weight, and successful weight loss maintainers. Obesity,
MacKillop, J, Amlung, M, Wier, L, David, SP, Ray, LA, Bickel, WK, Sweet, LH (2012). The neuroeconomics of nicotine dependence: An fMRI study of delay discounting in nicotine dependent adults. Psychiatry Research: Neuroimaging,
MacKillop, J, Brown, CL, Stojek. MK, Murphy, CM, Sweet, LH, Niaura, RS (2012). Behavioral Economic Analysis of Withdrawal- and Cue-elicited Craving for Tobacco: An Initial Investigation, Nicotine and Tobacco Research,
Cohen, RA and Sweet, LH (2011). Brain Imaging in Behavioral Medicine and Clinical Neuroscience, Springer, New York.
Sweet, LH (2011). Functional magnetic resonance imaging. In Cohen, RA, and Sweet, LH (Editors). Brain Imaging in Behavioral Medicine and Neuropsychology. Springer, New York.
Sweet, LH and Vanderhill, SD (2011). Multiple Sclerosis. In Cohen, RA, and Sweet, LH (Editors). Brain Imaging in Behavioral Medicine and Neuropsychology. Springer, New York.
David, SP, Sweet, LH, Cohen, R., Mulligan, RC, and Niaura, R (2011). Application of functional neuroimaging to examination of nicotine dependence. In Cohen, RA, and Sweet, LH (Editors). Brain Imaging in Behavioral Medicine and Neuropsychology. Springer, New York.
MacKillop, J, Amlung, MT, Few, LR, Ray, LA, Sweet, LH, Munafò, MR (2011). Delayed reward discounting and addictive behavior: a meta-analysis. Psychopharmacology (Berlin), 216(3), 305-21.
Friedman, JH, Abrantes, A, Sweet, LH (2011). Fatigue in Parkinson’s disease. Expert Opinion on Pharmacotherapy, 12(13), 1999-2007.
Sweet, LH, Vanderhill, SD, Jerskey, BA, Gordon, N, Paul, RH, Cohen, RA (2010). Subvocal articulatory rehearsal during verbal working memory in multiple sclerosis. Neurocase, 16(5), 418-425.
Sweet, LH, Jerskey, BA, Aloia, MS (2010). Withdrawal of positive airway pressure treatment and default network response to a verbal working memory challenge in obstructive sleep apnea. Brain Imaging and Behavior, 4(2), 155-63.
Sweet, LH, Mulligan, RC, Finnerty, C, Jerskey, BA, Cohen, R, and Niaura, R (2010). Effects of nicotine withdrawal on verbal working memory. Psychiatry Research Neuroimaging, 183(1), 69-74.
Sweet, LH and Haley, AP (2010). Functional magnetic resonance imaging in patients with cardiovascular disease. In Cohen, RA, and Gunstad, JJ (Editors). Brain Function in Cardiovascular Disease. Oxford, New York.
McCaffery JM, Haley AP, Sweet LH, Phelan S, Raynor HA, Del Parigi A, Cohen R, Wing RR (2009). Differential functional magnetic resonance imaging response to food pictures in successful weight-loss maintainers relative to normal-weight and obese controls. American Journal of Clinical Nutrition, 90(4), 928-34.
Sweet, LH, Paskavitz, JF, Haley, AP, Gunstad, JJ, Nyalakanti, PK, Cohen, RA (2008). Imaging phonological similarity effects in verbal working memory. Neuropsychologia, 46, 114-1123.
Cohen, RA, Salloway, S, Sweet, LH (2008). Neuropsychiatric aspects of disorders of attention. In SC Yudofsky and RE Hales (Editors). Textbook of Neuropsychiatry. American Psychiatric Press, Washington, DC.
Sweet, LH, Rao, SM, Primeau, M, Durgerian, S, and Cohen, RA (2006). FMRI response to increased working memory demands among patients with Multiple Sclerosis. Human Brain Mapping, 27(1), 28-36.
Sweet, LH, Paskavitz, JF, O’Connor, MJ, Browndyke, JN, Wellen, JW, and Cohen, RA (2005). FMRI correlates of the WAIS-III Symbol Search subtest. Journal of the International Neuropsychological Society, 11(4), 471-476.