Andrea G. Hohmann, Ph.D.
- Professor
- Neuroscience and Behavior Program
- Ph.D. Brown University, 1996
- Office: Room 601
- Ph: (706) 542-2252
- Fax: (706) 542-3275
- Email: ahohmann {at} uga dt edu
Research Interests
My research studies behavior from physiological, neurochemical and anatomical perspectives. My work uses rat subjects to study mechanisms of pain and its control and specifically focuses on the roles of cannabinoids- the bodies' own marijuana-like compounds- in suppressing pain. My laboratory is particularly interested in identifying the environmental conditions under which an endogenous cannabinoid system is active. My research program uses electrophysiological methods to study cannabinoid modulation of nociceptive neurons. To address the underlying mechanisms, my research has identified the locations of cannabinoid receptors in primary pain pathways using the techniques of in situ hybridization and in vitro receptor binding/ autoradiography. I am especially interested in studying how this system may be activated to treat chronic pain - a significant clinical problem - that responds poorly to conventional treatments.
Selected Publications
Nackley, A.G., Zvonok, A.M., Makriyannis, A., and Hohmann, A.G. (2004) Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. J. Neurophysiology, in press. Online version published Aug. 18, 2004 as DOI: 10.1152/jn.00886.2003.
Hohmann, A.G., Farthing, J., Zvonok, A.M. and Makriyannis, A. (2004) Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin. Journal of Pharmacology and Experimental Therapeutics, 308: 446-453.
Nackley, A.G. Suplita, R.L II and Hohmann, A.G. (2003) A peripheral cannabinoid mechanism suppresses spinal Fos protein-expression and pain behavior in a rat model of inflammation. Neuroscience 117: 659-670.
Nackley, A.G., Makriyannis, A. and Hohmann, A.G. (2003) Selective activation of cannabinoid CB2 receptors suppresses spinal Fos protein expression and pain behavior in a rat model of inflammation. Neuroscience 119: 747-757.
Crystal, J.D., Maxwell, K.W. and Hohmann, A.G. (2003) Cannabinoid modulation of sensitivity to time. Behavioural Brain Research 144: 57-66.
Hohmann, A.G. and Herkenham, M. (2000) Localization of cannabinoid CB1 receptor mRNA in neuronal subpopulations of rat striatum: A double-label in situ hybridization study. Synapse 37: 71-80.
Ruda, M.A., Ling, Q.D., Hohmann, A.G., Peng, Y.B. and Tachibana, T. (2000) Altered nociceptive neuronal circuits after neonatal peripheral inflammation. Science 289: 628-630.
Hohmann, A.G., and Herkenham, M. (1999) Cannabinoid receptors undergo axonal flow in sensory nerves. Neuroscience 92, 1171-1175.
Hohmann, A.G. and Herkenham, M. (1999) Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: A double-label in situ hybridization study. Neuroscience, 90: 923-931.
Hohmann, A.G., Briley E.M. and Herkenham, M. (1999) Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord. Brain Research, 822: 17-25.
Hohmann, A.G., Tsou, K. and Walker, J.M. (1999) Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat. Journal of Neurophysiology, 81: 575-583.
Zimmer, A., Zimmer, A.M., Hohmann, A.G., Herkenham, M. and Bonner, T.I. (1999) Increased mortality, hypoactivity and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proceedings of the National Academy of Sciences, 96: 5780-5785.
Walker, J.M., Hohmann, A.G., Martin, W.J., Strangman, N.M., Huang, S.M. and Tsou, K. (1999) The neurobiology of cannabinoid antinociception. Life Sciences 65, 665-673.
